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Integration of macromolecular complex data into the Saccharomyces Genome Database
Edith D Wong1, Marek S Skrzypek1, Shuai Weng1
1Department of Genetics, Stanford University, Porter Drive, Palo Alto, CA, USA.
Database : the Journal of Biological Databases and Curation
|February 5, 2019
Summary
The Saccharomyces Genome Database now integrates comprehensive budding yeast macromolecular complex data. This resource aids researchers by detailing complex composition, function, and subunit interactions for cellular process understanding.
Area of Science:
- Molecular Biology
- Systems Biology
- Bioinformatics
Background:
- Proteins rarely function in isolation, instead forming macromolecular complexes crucial for cellular processes.
- Understanding these complexes is vital for elucidating biological pathways.
- The Saccharomyces Genome Database (SGD) aims to provide a comprehensive view of budding yeast biology.
Purpose of the Study:
- To manually curate and integrate the complete budding yeast complexome into the SGD core database.
- To enhance data accessibility for researchers studying yeast macromolecular complexes.
- To provide detailed, referenced information on complex composition, function, and subunit interactions.
Main Methods:
- Collaboration with the EMBL-EBI Complex Portal for manual curation of 589 yeast complexes.
- Integration of curated complex data into the SGD core database.
- Development of complex-specific reports and network diagrams.
Main Results:
- Successfully incorporated data for 589 budding yeast macromolecular complexes into SGD.
- Developed easily accessible, complex-specific web pages with referenced summaries.
- Generated network diagrams illustrating subunit interactions and shared Gene Ontology annotations.
Conclusions:
- The integrated macromolecular complex data in SGD provides a valuable resource for yeast research.
- Enhanced data presentation facilitates understanding of complex composition, function, and subunit dynamics.
- Ongoing collaboration with the Complex Portal ensures continued updates and data enrichment.
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