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Updated: Jan 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Gender-Based Differences in Cardiac Resynchronization Therapy Response.

Marin Nishimura1, Ulrika Birgersdotter-Green2

  • 1Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 7411, La Jolla, CA 92037-7411, USA.

Cardiac Electrophysiology Clinics
|February 6, 2019
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) offers significant benefits for systolic heart failure patients. Women experience greater CRT benefits than men, even with less QRS prolongation.

Keywords:
Cardiac resynchronization therapyGenderLBBBQRS

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Area of Science:

  • Cardiology
  • Heart Failure Management
  • Cardiac Electrophysiology

Background:

  • Cardiac resynchronization therapy (CRT) improves outcomes in systolic heart failure.
  • CRT enhances reverse remodeling, quality of life, and survival.
  • Women are underrepresented in CRT clinical trials but show significant benefits.

Purpose of the Study:

  • To analyze the therapeutic benefits of CRT in women compared to men.
  • To investigate the relationship between QRS duration and CRT benefit in women.

Main Methods:

  • Review of clinical trial data on CRT efficacy.
  • Comparative analysis of CRT outcomes based on sex and QRS duration.

Main Results:

  • Women derive greater therapeutic benefit from CRT than men.
  • Women benefit from CRT at lower QRS prolongation thresholds compared to men.
  • The generally accepted QRS duration cutoff of ≥150 milliseconds may not be optimal for identifying all women who benefit from CRT.

Conclusions:

  • CRT is a valuable therapy for systolic heart failure, with enhanced efficacy in women.
  • Sex-specific considerations for CRT eligibility, particularly regarding QRS duration, are warranted.
  • Further research should focus on optimizing CRT selection criteria for female patients.