Evolving Role of Permanent His Bundle Pacing in Conquering Dyssynchrony
Parikshit S Sharma1, Pugazhendhi Vijayaraman2
1Division of Cardiology, Rush University Medical Center, 1725 West Harrison Street Suite 1159, Chicago, IL 60612-3841, USA.
Cardiac Electrophysiology Clinics
|February 6, 2019
Summary
Permanent His bundle pacing (PHBP) offers clinical advantages over traditional pacing methods. It is increasingly used to address interventricular dyssynchrony, improving patient outcomes.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Pacing
Background:
- Conventional right ventricular pacing can lead to interventricular dyssynchrony.
- Permanent His bundle pacing (PHBP) presents an alternative pacing strategy.
- PHBP has demonstrated clinical benefits in select patient populations.
Purpose of the Study:
- To review the mechanisms by which PHBP addresses interventricular dyssynchrony.
- To summarize the current data supporting the use of PHBP in dyssynchronous patients.
- To highlight the emerging role of PHBP in cardiac pacing.
Main Methods:
- Literature review of studies on Permanent His bundle pacing.
- Analysis of data concerning interventricular dyssynchrony.
- Synthesis of evidence on PHBP's efficacy in managing dyssynchrony.
Main Results:
- PHBP effectively paces the His-Purkinje system, promoting more physiological ventricular activation.
- Studies indicate PHBP can improve interventricular synchrony compared to right ventricular pacing.
- Clinical data suggest improved heart failure metrics and reduced pacing-induced cardiomyopathy with PHBP.
Conclusions:
- Permanent His bundle pacing is a viable and beneficial strategy for patients with interventricular dyssynchrony.
- PHBP offers a more synchronized ventricular activation, potentially mitigating adverse remodeling.
- Further research continues to define the optimal role of PHBP in cardiac pacing.
Related Concept Videos
01:02Role of Septins
2.2K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
01:23The Role of Culture
410
Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
410
01:21Role-Based Identity
203
Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
203
01:19Role of Hippocampus in Memory
1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
01:17Role of ER in the Secretory Pathway
7.1K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
7.1K
01:16Role of Amygdala in Memory
1.2K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
1.2K