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[Classical and extrahepatic presentation of acute hepatitis E infection]
Kasper Gaardsted Mortensen1, Maya Svenningsen, Steffen Leth
1kaspmort@rm.dk.
Ugeskrift for Laeger
|February 7, 2019
Summary
Hepatitis E virus (HEV) infection presented atypically in two Danish patients, one with neurological symptoms. Both recovered spontaneously, highlighting HEV as a crucial differential diagnosis for unexplained liver enzyme elevation and extrahepatic signs.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis E virus (HEV) is a significant cause of acute hepatitis globally.
- Transmission routes are diverse, including zoonotic and waterborne pathways.
- HEV infection can manifest with varied clinical presentations.
Observation:
- Two Danish patients with HEV infection were identified.
- The transmission route for both cases was unclear.
- One patient exhibited typical hepatitis symptoms, while the other presented with neurological manifestations.
Findings:
- Both patients experienced a self-limiting course of HEV infection.
- Neither patient required specific antiviral treatment for recovery.
- HEV infection was confirmed despite the absence of known exposure history.
Implications:
- HEV should be considered in the differential diagnosis of elevated liver enzymes.
- Extrahepatic symptoms associated with HEV warrant further investigation.
- This case report underscores the importance of considering HEV in patients with unexplained hepatitis and neurological symptoms.
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