Related Experiment Video

Updated: Jan 29, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

8.2K

Recent advances in understanding necrotizing enterocolitis

Mashriq Alganabi1, Carol Lee1, Edoardo Bindi1

  • 1Division of General and Thoracic Surgery, Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

F1000Research
|February 12, 2019
PubMed

Insights

Necrotizing enterocolitis (NEC) is a severe intestinal disease in preterm infants. This review covers NEC epidemiology, risk factors, pathophysiology, and current/emerging management strategies.

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Pediatric Surgery

Background:

  • Necrotizing enterocolitis (NEC) is a critical intestinal disease impacting premature infants.
  • Despite advances in neonatal care, mortality rates for NEC, particularly in advanced stages, remain high.
  • Key aspects of NEC, including disease mechanisms, injury progression, and optimal management, are subjects of ongoing research and debate.

Purpose of the Study:

  • To provide a comprehensive overview of the current understanding of necrotizing enterocolitis.
  • To review the epidemiology, risk factors, and pathophysiology of NEC.
  • To discuss current therapeutic approaches and highlight emerging research for future directions.

Main Methods:

  • Literature review of necrotizing enterocolitis.
  • Analysis of epidemiological data and risk factors.
  • Synthesis of current knowledge on pathophysiology and management.

Main Results:

  • NEC affects preterm infants, with high mortality in advanced cases.
  • Understanding of NEC epidemiology, risk factors, and pathophysiology is evolving.
  • Current management strategies exist, with promising new research avenues.

Conclusions:

  • NEC remains a significant challenge in neonatal intensive care.
  • Further research into NEC mechanisms and treatments is crucial.
  • Improved understanding and novel strategies are needed to reduce NEC-related mortality.

Keywords:
necrotizing enterocolitis (NEC)neonatespathophysiologypremature

More Related Videos

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

2.8K
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

4.1K

Related Concept Videos

Understanding the Self01:28

Understanding the Self

The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
283
Understanding Self-Concept01:20

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
272
Understanding Deception01:14

Understanding Deception

Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
166
Understanding Love01:27

Understanding Love

Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
189
Understanding Consciousness01:23

Understanding Consciousness

Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
2.1K
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.5K