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Histopathological Prognostic Factors for Colic Adenocarcinoma.
A M Al Khatib1, A E Stepan2, C Mărgăritescu2
1PhD student, Department of Pathology, University of Medicine and Pharmacy of Craiova.
This study investigated colorectal adenocarcinoma risk factors in 144 patients. Results show significant links between tumor stage, differentiation grade, and vascular invasion in colorectal cancer.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Colorectal carcinomas, primarily adenocarcinomas, often present as moderately differentiated tumors.
- Understanding histopathological risk factors is crucial for managing colorectal cancer (CRC).
Purpose of the Study:
- To determine the incidence of colorectal cancer (CRC).
- To analyze the relationship between histopathological risk factors and outcomes in patients with colic adenocarcinomas.
Main Methods:
- Analysis of 144 CRC cases diagnosed in 2017.
- Histopathological examination of colectomy and hemicolectomy samples using hematoxylin and eosin staining.
- Evaluation of parameters including pattern, grading, stage, vascular invasion, and neural invasion.
Main Results:
- The average age at diagnosis was 68.6 years, with a male predominance (64.6%).
- Mucinous pattern (31.9%) and cribriform comedocarcinoma (29.9%) were most common.
- Stage III B (34%), moderate differentiation (64.6%), vascular invasion (47.2%), and perineural invasion (25.7%) were prevalent.
- Significant associations were found between tumor stage and differentiation grade (p<0.01), and tumor stage and vascular invasion (p<0.05).
Conclusions:
- Histopathological factors like differentiation grade and vascular invasion are significantly related to tumor stage in colorectal adenocarcinomas.
- These findings highlight the importance of detailed histopathological analysis for prognostic assessment in colorectal cancer patients.
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