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Updated: Jan 29, 2026

Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
Fatal Disseminated Herpes Simplex in a very premature neonate
Ranjit I Kylat1, Joel Addams2, Richard E Sobonya2
1University of Arizona, College of Medicine, Department of Pediatrics. Tucson, AZ, USA.
Abstract:
Herpes Simplex Virus infections (HSV) are ubiquitous. The neonatal HSV infection (NHSV) is rare. The incidence is estimated globally at only 10.3 per 100,000 births, but it can cause devastating disease in premature infants. Both HSV-1 and HSV-2 can be the etiologic agents in this type of vertically transmittted NHSV infection. Here we describe the pathological findings from a complete autopsy of a very low birth weight infant who succumbed to the infection despite early institution of antiviral treatment. We urge more awareness of this disease with continued surveillance; every effort should be taken to make an early diagnosis and thus prevent this devastating disease.
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