Related Experiment Video

Updated: Jan 29, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.6K

Does drug induced sleep endoscopy-directed surgery improve polysomnography measures in children with Down Syndrome

Sarah R Akkina1, Cheng C Ma2, Erin M Kirkham1,3

  • 1a Otolaryngology , University of Washington , Seattle , WA , USA.

Acta Oto-Laryngologica
|February 19, 2019
PubMed

Insights

Drug-induced sleep endoscopy (DISE)-directed surgery shows promise for children with Down syndrome (DS) and obstructive sleep apnea (OSA). While improvements were noted in sleep study measures, only oxygen saturation significantly improved in those with prior surgery.

Area of Science:

  • Pediatric Otolaryngology
  • Sleep Medicine
  • Genetics

Background:

  • Obstructive sleep apnea (OSA) in children with Down syndrome (DS) presents treatment challenges.
  • First-line therapies often yield limited success for this population.
  • Drug-induced sleep endoscopy (DISE)-directed surgery offers a potential alternative treatment approach.

Purpose of the Study:

  • To evaluate the effectiveness of DISE-directed surgery in improving polysomnography (PSG) measures in pediatric patients with DS and OSA.
  • To compare outcomes between surgically naive patients and those with a history of adenotonsillectomy.

Main Methods:

  • Retrospective chart review of 24 pediatric patients with DS and OSA who underwent DISE-directed surgery.
  • Analysis of pre- and post-operative PSG data, including apnea-hypopnea index (AHI), obstructive AHI, oxygen nadir, oxygen desaturation index (ODI), and mean carbon dioxide levels.
  • Statistical comparison using two-sided t-tests, with patients grouped by prior adenotonsillectomy status.

Main Results:

  • All PSG parameters showed improvement post-surgery in the cohort of 24 patients (14 surgically naive, 10 with prior adenotonsillectomy).
  • A statistically significant improvement in oxygen nadir was observed in the group with prior adenotonsillectomy (88.5% to 90.9%, p=0.04).
  • No other parameters reached statistical significance in either group.

Conclusions:

  • DISE-directed surgery may be a beneficial intervention for children with DS and OSA, leading to observed improvements in key PSG measures.
  • Further investigation with larger, prospective studies is recommended to fully elucidate the utility of DISE in this patient population.
Abstract

Keywords:
DISEDown syndromeTrisomy 21drug-induced sleep endoscopyobstructive sleep apneapolysomnography

More Related Videos

Quantitative Measurement of the Immune Response and Sleep in Drosophila12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K
Polygraphic Recording Procedure for Measuring Sleep in Mice08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.2K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
531
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
918
Stages of Sleep01:22

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.5K
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
966
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
423