Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

750
A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in...
750
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants

2.1K

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.1K
Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels01:31

Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels

593
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
593
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

562
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
562

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

N-Isocaproyl-L-Arginylglycine Hexamethylenediamide, First Low-Molecular-Weight Mimetic of Neurotrophin-4: Design and Neuroprotective Activity.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2026
Same author

Influence of Retrodipeptide Analogue of Cholecystokinin Tetrapeptide (GB-115) and Phenazepam on the Behavior of Rhesus Monkeys under Isolation Conditions.

Doklady. Biochemistry and biophysics·2025
Same author

Study of the Pharmacological Activity Spectrum of the New Original NT-3 Mimetic Dipeptide GTS-302.

Doklady. Biochemistry and biophysics·2025
Same author

Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic.

Doklady. Biochemistry and biophysics·2023
Same author

Pharmacogenetic Analysis of the Interaction of the Low-Molecular-Weight BDNF Mimetic Dipeptide GSB-106 with TRK Receptors.

Doklady. Biochemistry and biophysics·2023
Same author

Specifics of Experimental Modeling 8-OH-DPAT-Induced Perseverative Behavior in Mice.

Bulletin of experimental biology and medicine·2023

Related Experiment Video

Updated: Jan 28, 2026

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line
08:23

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

11.8K

Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation.

L F Zainullina1, T V Ivanova2, R U Ostrovskaya1

  • 1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

Bulletin of Experimental Biology and Medicine
|February 22, 2019
PubMed
Summary

Noopept, a nootropic drug, was investigated for its potential to stimulate cell growth. Studies on HEK293 and SH-SY5Y cells found that Noopept does not affect cell cycle progression or the proliferation marker Ki-67, indicating it does not promote cell proliferation.

Keywords:
Ki-67NoopeptPro-Gly substituted dipeptidescell cycleproliferation

More Related Videos

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.3K
Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry
07:17

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry

Published on: October 30, 2019

7.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line
08:23

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

11.8K
Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.3K
Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry
07:17

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry

Published on: October 30, 2019

7.2K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a nootropic agent with a known multifactorial mechanism of action.
  • Its effects include enhancing neurotrophin NGF and BDNF expression and increasing HIF-1 activity.
  • The potential mitogenic effects of Noopept warrant investigation.

Purpose of the Study:

  • To evaluate the impact of Noopept on cell proliferation.
  • To assess the effects of Noopept on cell cycle parameters.
  • To determine the influence of Noopept on the proliferation marker Ki-67.

Main Methods:

  • Experiments were conducted using HEK293 and SH-SY5Y cell lines.
  • Cell cycle distribution across G1, S, and G2 phases was analyzed.
  • The relative level of the proliferation marker Ki-67 was quantified.

Main Results:

  • Noopept did not alter the distribution of cells in the G1, S, or G2 phases of the cell cycle.
  • The relative level of the proliferation marker Ki-67 remained unaffected by Noopept treatment.
  • No significant changes in cell cycle parameters or Ki-67 levels were observed.

Conclusions:

  • Noopept does not appear to stimulate cell growth or proliferation.
  • The drug's mechanism of action does not involve the direct stimulation of cell division.
  • These findings contribute to understanding the safety profile and cellular effects of Noopept.