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Choroidal vasculature imaging with laser Doppler holography
Léo Puyo1,2, Michel Paques2,3,4, Mathias Fink1,2
1Institut Langevin, Centre National de la Recherche Scientifique (CNRS), Paris Sciences & Lettres (PSL University), École Supérieure de Physique et de Chimie Industrielles (ESPCI Paris), 1 rue Jussieu, 75005 Paris, France.
Biomedical Optics Express
|February 26, 2019
Summary
Laser Doppler holography offers high-contrast imaging of human choroidal vessels, matching current technologies. This method can differentiate arteries and veins, enhancing choroidal vascular network studies.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Vascular Biology
Background:
- The choroid, a vital vascular tissue, is increasingly implicated in retinal diseases.
- Current methods for investigating choroidal anatomy and flow face significant challenges.
- Understanding choroidal vascularization is crucial for diagnosing and treating eye conditions.
Purpose of the Study:
- To introduce and evaluate laser Doppler holography (LDH) for imaging the human choroidal vasculature.
- To assess the spatial resolution and contrast of LDH compared to existing imaging modalities.
- To explore LDH's capability in differentiating choroidal arteries and veins.
Main Methods:
- Application of laser Doppler holography to image choroidal vessels in human subjects.
- Comparison of LDH's spatial resolution with indocyanine green angiography (ICGA) and optical coherence tomography (OCT).
- Utilizing power Doppler spectral analysis to distinguish between choroidal arteries and veins.
Main Results:
- LDH achieved high-contrast imaging of choroidal vessels.
- The spatial resolution of LDH was found to be comparable to ICGA and OCT.
- Power Doppler spectral analysis enabled the differentiation of choroidal arteries and veins.
Conclusions:
- Laser Doppler holography is a promising technique for high-resolution, high-contrast imaging of the human choroidal vascular network.
- LDH offers the ability to distinguish between arterial and venous flow within the choroid.
- This technology has the potential to significantly advance the study of choroidal anatomy and hemodynamics in health and disease.
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