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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

1.0K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Vaccinations01:51

Vaccinations

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Overview
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Updated: Jan 28, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
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Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

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Cancer Vaccines.

Peter J DeMaria1, Marijo Bilusic2

  • 1Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B2L312, Bethesda, MD 20892, USA.

Hematology/Oncology Clinics of North America
|March 6, 2019
PubMed
Summary
This summary is machine-generated.

Therapeutic cancer vaccines, a key part of immuno-oncology, are well-tolerated and can target tumors. Ongoing research aims to enhance their effectiveness through new targets and combination therapies.

Keywords:
Antigen cascadeCancer immunotherapyCancer vaccineImmuno-oncologyTherapeutic cancer vaccineVaccine

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Area of Science:

  • Immuno-oncology
  • Cancer vaccine development

Background:

  • Therapeutic cancer vaccines represent a significant advancement in oncology.
  • They differ from prophylactic vaccines, utilizing diverse target antigens and platforms.
  • Three FDA-approved therapeutic cancer vaccines include intravesical BCG live, sipuleucel-T, and T-VEC.

Purpose of the Study:

  • To summarize the current landscape of therapeutic cancer vaccines.
  • To highlight their distinct characteristics and clinical trial findings.
  • To outline future directions in cancer vaccine research.

Main Methods:

  • Review of existing literature and FDA-approved therapeutic cancer vaccines.
  • Analysis of clinical trial data regarding vaccine tolerability and kinetics.
  • Identification of ongoing research strategies for improved efficacy.

Main Results:

  • Therapeutic cancer vaccines are generally well-tolerated in clinical trials.
  • Vaccines demonstrate unique kinetic profiles and the ability to induce antigen cascade.
  • Existing vaccines target specific antigens, with potential for neoantigen targeting.

Conclusions:

  • Therapeutic cancer vaccines are a promising strategy in immuno-oncology.
  • Further research focuses on novel antigen targets and combination therapies to boost efficacy.
  • Ongoing trials are crucial for advancing cancer treatment through vaccination.