Related Experiment Video

Updated: Jan 28, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.9K

Immunotherapy Toxicity

Charlene M Mantia1, Elizabeth I Buchbinder2

  • 1Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

Hematology/Oncology Clinics of North America
|March 6, 2019
PubMed

Insights

Immunotherapy using immune checkpoint inhibitors like CTLA-4, PD-1, and PD-L1 blockers has advanced cancer treatment. These therapies can cause immune-related adverse events affecting various organs.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Cancer immunotherapy has significantly improved treatment outcomes for various malignancies.
  • Immune checkpoint inhibitors (ICIs) represent a major advancement, enhancing the immune system's ability to target cancer cells.

Purpose of the Study:

  • To provide an overview of immune checkpoint inhibitors in cancer treatment.
  • To discuss the efficacy and potential side effects of these novel therapies.

Main Methods:

  • Review of current literature on immune checkpoint inhibitors.
  • Analysis of approved ICI targets including CTLA-4, PD-1, and PD-L1.
  • Summarization of common and potential immune-related adverse events.

Main Results:

  • Immune checkpoint inhibitors targeting CTLA-4, PD-1, and PD-L1 are approved for numerous localized and advanced cancers.
  • These therapies work by blocking inhibitory signaling pathways, thereby unleashing anti-tumor immune responses.

Conclusions:

  • Immune checkpoint inhibitors offer a powerful new modality in cancer therapy.
  • Awareness and management of immune-related adverse events are crucial for patient safety and treatment success.
Keywords:
Immune checkpoint inhibitorsImmune-related adverse eventsImmunotherapyToxicity

More Related Videos

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.6K
Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model08:06

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

20.2K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.9K
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.6K
Predator-Prey Interactions02:39

Predator-Prey Interactions

Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.4K
Responses to Salt Stress02:02

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
Comparative Excretory Systems02:24

Comparative Excretory Systems

Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.6K