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Updated: Jan 28, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Immunotherapy Toxicity.

Charlene M Mantia¹, Elizabeth I Buchbinder²

¹Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

Hematology/Oncology Clinics of North America

|March 6, 2019

Summary

This summary is machine-generated.

Immunotherapy using immune checkpoint inhibitors like CTLA-4, PD-1, and PD-L1 blockers has advanced cancer treatment. These therapies can cause immune-related adverse events affecting various organs.

Keywords:

Immune checkpoint inhibitors Immune-related adverse events Immunotherapy Toxicity

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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

Area of Science:

Oncology
Immunology

Background:

Cancer immunotherapy has significantly improved treatment outcomes for various malignancies.
Immune checkpoint inhibitors (ICIs) represent a major advancement, enhancing the immune system's ability to target cancer cells.

Purpose of the Study:

To provide an overview of immune checkpoint inhibitors in cancer treatment.
To discuss the efficacy and potential side effects of these novel therapies.

Main Methods:

Review of current literature on immune checkpoint inhibitors.
Analysis of approved ICI targets including CTLA-4, PD-1, and PD-L1.
Summarization of common and potential immune-related adverse events.

Main Results:

Immune checkpoint inhibitors targeting CTLA-4, PD-1, and PD-L1 are approved for numerous localized and advanced cancers.
These therapies work by blocking inhibitory signaling pathways, thereby unleashing anti-tumor immune responses.

Conclusions:

Immune checkpoint inhibitors offer a powerful new modality in cancer therapy.
Awareness and management of immune-related adverse events are crucial for patient safety and treatment success.