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M G Poltavskaya1, E I Emelina, Yu V Avdeev

  • 1I. M. Sechenov First Moscow State Medical University (Sechenov University).. fake@neicon.ru.

Kardiologiia
|March 12, 2019
PubMed
Summary

Radiation therapy can cause heart valve damage, with nearly half of patients developing issues like mitral regurgitation. While most valve damage is mild, significant lesions can occur, requiring careful monitoring after cancer treatment.

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Kardiologiia·2022

Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Radiation therapy (RT) is crucial in cancer treatment, yet can lead to significant complications.
  • Heart valve lesions are a notable adverse effect of RT.

Purpose of the Study:

  • To investigate the types of heart valve damage in cancer patients treated with radiation therapy.

Main Methods:

  • A cohort of 71 Hodgkin's lymphoma patients treated with chemo-radiation therapy (CRT) between 1978-2002 were assessed.
  • Utilized clinical examination, spirometry, ECG monitoring, echocardiography, SPECT, CT scans, and stress tests (treadmill, ergospirometry).

Main Results:

  • Valve pathology was identified in 49.3% of patients.
  • Mitral regurgitation (MR), primarily grade 1, was most common (46.5%).
  • Aortic valve issues, including mild regurgitation (11.3%) and stenosis (4.2%), were also observed.

Conclusions:

  • The study found predominantly non-severe valve lesions in patients treated with RT.
  • While most detected valve pathologies were mild, clinically significant valvular lesions were also observed, highlighting the need for cardiac monitoring.

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