Related Experiment Video
Updated: Jan 27, 2026

A Murine Tail Lymphedema Model
Published on: February 10, 2021
Effectiveness of Vascularized Lymph Node Transfer for Extremity Lymphedema Using Volumetric and Circumferential
Olivia A Ho1, Sung-Yu Chu2, Yen-Ling Huang2
1Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Circumferential measurements are a reliable and cost-effective method for assessing lymphedema, comparable to computed tomography (CT) scans. This study confirms their accuracy in tracking limb volume changes post-treatment.
Area of Science:
- Medical imaging
- Lymphedema management
- Surgical outcomes
Background:
- Lymphedema limb size is traditionally measured by circumferential differences.
- Computed tomography (CT) offers accurate volumetric limb assessment.
- Comparing these methods is crucial for effective lymphedema management.
Purpose of the Study:
- To compare the accuracy and cost-effectiveness of CT imaging versus circumferential measurements for lymphedema.
- To assess the correlation between these two measurement modalities.
Main Methods:
- Comparison of CT and circumferential difference measurements in patients undergoing vascularized lymph node transfer.
- Analysis of costs associated with each measurement method.
- Statistical correlation analysis between the two techniques.
Main Results:
- Both CT and circumferential measurements showed significant reductions in limb size post-operatively.
- CT volume measurements strongly correlated with circumferential differences (r = +0.7, P = 0.03).
- Circumferential measurements were significantly more cost-effective than CT scans across multiple financial and time metrics.
Conclusions:
- Standardized circumferential measurements are a reliable, reproducible, and accurate method for assessing lymphedema.
- These measurements are comparable to CT volumetric assessments.
- Circumferential measurements offer a minimally invasive, low-cost alternative for monitoring lymphedema progression and treatment efficacy.
Related Concept Videos
Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Absolute and Local Extreme Values
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Electric Potential and Potential Difference
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
Seedless Vascular Plants
Identifying Statistically Significant Differences: The F-Test

