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Updated: Jan 27, 2026

Expression of Fluorescent Fusion Proteins in Murine Bone Marrow-derived Dendritic Cells and Macrophages
Published on: October 30, 2018
Cellular Composition and Expression of Cell Proliferation and Apoptosis Markers in Bone Marrow Cells after
O V Vorob'yova1, L A Lyubovtseva2
1Department of General and Clinical Morphology and Forensic Medicine, I. N. Ulyanov Chuvash State University, Cheboksary, Chuvash Republic, Russia. olavorobeva@mail.ru.
Abstract:
The effects of heterotransplantation on bone marrow structures were studied in experimental male mice. Suspension of the bone marrow from feline femur (1 ml bone marrow diluted in isotonic saline, 1:2) was injected into the caudal vein. Heterotransplantation led to an increase in the level of serotonin involved in cell differentiation. In 2 days, the counts of all cells except erythroid cells decreased. Immunohistochemical analysis of Ki-67 marker within 40 min after transplantation showed a significant increase of cell proliferative activity in comparison with that in intact mice. At later terms, the expression of Ki-67 in bone marrow cells decreased, while the expression of apoptosis regulator P-53 increased, which was associated with the presence of numerous dead cells.
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