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Updated: Jan 5, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
Effects of Bone Marrow Autotransplantation on the Bone Marrow Neurotransmitter Structures
O V Vorob'yova1, L A Lyubovtseva2, E A Guryanova2
1Department of Common and Clinical Morphology and Forensic Medicine, I. N. Ulyanov Chuvash State University, Cheboksary, Chuvash Republic, Russia. olavorobeva@mail.ru.
Abstract:
Morphological structures involved in local regulation of tissue processes and the neurotransmitters they produce are assumed to play an important role in the pathogenesis of oncological diseases. We studied the dynamics of neurotransmitter cell counts and distribution of catecholamines and serotonin in them and analyzed proliferative activity of hemopoietic cells in the bone marrow of mice after bone marrow autotransplantation. The bone marrow of male mice was studied by fluorescent and immunohistochemical methods after injection of the bone marrow from the same mouse into the caudal vein. The count of neurotransmitter cells and the cell proliferation index increased after bone marrow autotransplantation.
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