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Biomimetic Approaches Toward Smart Bio-hybrid Systems
Zhiqiang Luo1, Dara E Weiss2, Qingyun Liu1
1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China.
Nano Research
|March 26, 2019
Summary
Smart bio-hybrid systems merge living and artificial components for novel applications. This review highlights advances in 3D bio-integrated devices, neural interfaces, and cell-enabled soft robotics.
Area of Science:
- Biomaterials Science
- Bioelectronics
- Tissue Engineering
Background:
- Bio-integrated materials and devices are advancing the synergy between biological and artificial systems.
- Microfluidics, bioelectronics, and nanostructures enable close biological interactions at cellular and tissue levels.
- Emerging applications include organ-on-a-chip systems, biodegradable implants, and neuro-prosthetic tools.
Purpose of the Study:
- To review recent advances in the fabrication and application of smart bio-hybrid systems.
- To emphasize three-dimensional (3D) bio-integrated devices mimicking tissue scaffolds.
- To discuss neural integration with nanostructures and cell-enabled soft robotics.
Main Methods:
- Review of recent literature on bio-integrated materials and devices.
- Focus on fabrication techniques for 3D bio-integrated systems.
- Analysis of applications in neuromodulation and soft robotics.
Main Results:
- Highlighting recent progress in smart bio-hybrid systems, particularly 3D bio-integrated devices.
- Discussing the integration of neurons with nanostructures for wireless neuromodulation.
- Examining the development of cell-enabled soft robotics requiring tight synthetic-biological coupling.
Conclusions:
- Bio-integrated systems offer diverse applications by blurring lines between living and artificial systems.
- Advancements in 3D bio-integration and neural interfaces are key.
- Biomimetic micro- and nanostructures are crucial for enhancing bio-integration.
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