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Updated: Jan 27, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum
Olga V Kuznetsova1, Irina S Reshetnikova, Sergei N Shtykov
1Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow, Russian Federation. andrei.timerbaev@univie.ac.at.
Abstract:
A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed. Based on ultrafiltration of a human serum-nanoparticle mixture and the mass spectrometric analysis of filtrates, this assay revealed for iron oxide nanoparticles coated with poly(acrylic acid) satisfactory biopersistence and a bimodal binding to sulfur-containing biomolecules, with the formation of the protein corona completed in about 1 h.
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