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Updated: Jan 27, 2026
09:06
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
Published on: February 3, 2023
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PROGRAMMED CELL DEATH-LIGAND 1 OVEREXPRESSION IN THYROID CANCER
Summary
Programmed cell death-ligand 1 (PD-L1) is expressed in thyroid cancer, potentially predicting recurrence and prognosis. This finding highlights PD-L1 as a novel immunotherapy target for advanced thyroid cancers.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Programmed cell death-ligand 1 (PD-L1) expression is linked to treatment response in various cancers.
- PD-L1 has been observed in thyroid cancer tissues, suggesting its potential role.
Purpose of the Study:
- To review the predictive and therapeutic potential of PD-L1 in thyroid cancer.
- To explore PD-L1 as a biomarker for thyroid cancer recurrence and prognosis.
Main Methods:
- Literature search of PubMed using terms "PD-L1," "B7-H1," and "thyroid cancer."
- PD-L1 positivity assessed via immunohistochemical assay.
Main Results:
- PD-L1 positivity ranged from 6.1% to 82.5% in papillary thyroid cancer (PTC) and 22.2% to 81.2% in anaplastic thyroid cancer (ATC).
- Higher PD-L1 expression in ATC than PTC, and in tumor tissue versus nontumor tissue.
- PD-L1 expression correlated with increased aggressiveness and recurrence, and decreased differentiation and outcomes.
Conclusions:
- PD-L1 serves as a potential biomarker for predicting thyroid cancer recurrence and prognosis.
- PD-L1 represents a novel immunotherapy target for radioiodine-refractory and anaplastic thyroid cancers (ATCs).
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