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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
Hypercaloric Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Experimental Models
Natália Pinheiro-Castro1, Lívia Beatriz Aparecida Ribeiro Silva1, Gabriela Machado Novaes1
1Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, and Food Research Center (FoRC), São Paulo, Brazil.
Abstract:
Overnutrition and obesity have developed into a major public health problem across different parts of the world. Epidemiological studies have shown that excessive intake of dietary components, such as fatty acids and/or sugars, can promote obesity. In this context, the use of dietary intervention in animal models that respond to a diet similar to humans is useful to understand this preventable, multifactorial disease. The aim of this chapter is to aid researchers in choosing specific nutritional interventions and animal strains to induce obesity and obesity-related morbidities in experimental models.
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