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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Breathing01:05

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The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
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Gas Exchange and Transport01:20

Gas Exchange and Transport

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Gas exchange, the intake of molecular oxygen (O2) from the environment and the outflow of carbon dioxide (CO2) into the environment, is necessary for cellular function. Gas exchange during respiration occurs largely via the movement of gas molecules along pressure gradients. Gas travels from areas of higher partial pressure to areas of lower partial pressure. In mammals, gas exchange occurs in the alveoli of the lungs, which are adjacent to capillaries and share a membrane with them.
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Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

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The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
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Related Experiment Video

Updated: Jan 26, 2026

Isolation and Purification of Murine Cardiac Pericytes
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Isolation and Purification of Murine Cardiac Pericytes

Published on: August 16, 2019

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Pericytes in the Lung.

Chi F Hung1, Carole L Wilson2, Lynn M Schnapp3

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.

Advances in Experimental Medicine and Biology
|April 3, 2019
PubMed
Summary
This summary is machine-generated.

Lung pericytes are key cells in lung health and disease. Research reveals their roles in fibrosis, inflammation, and vascular conditions, opening new avenues for treatment.

Keywords:
Lung developmentLung inflammationLung injuryLung myofibroblastsLung pericytesPDGFRβPulmonary fibrosis

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Last Updated: Jan 26, 2026

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Area of Science:

  • Pulmonary biology and cell research.
  • Vascular cell biology.
  • Immunology and disease pathogenesis.

Background:

  • The lung performs vital functions including gas exchange and immune defense.
  • Dual blood supply (pulmonary and bronchial circulation) highlights the importance of perivascular cells.
  • Pericytes, located in the perivascular niche, are increasingly recognized for their significant physiological roles.

Purpose of the Study:

  • To characterize lung pericytes molecularly, anatomically, and phenotypically.
  • To explore the origin and diverse functions of lung pericytes.
  • To discuss the role of lung pericytes in lung disease pathogenesis.

Main Methods:

  • Utilizing new genetic approaches to study lung pericyte biology.
  • Describing molecular and anatomical features of lung pericytes.
  • Phenotypical characterization of lung pericytes.

Main Results:

  • Lung pericytes are identified as myofibroblast progenitors involved in fibrosis.
  • Lung pericytes can respond to danger signals, amplifying inflammatory responses.
  • These cells elaborate cytokines and adhesion molecules.

Conclusions:

  • Lung pericytes are crucial in lung physiology and disease.
  • Their roles in pulmonary fibrosis, asthma, and pulmonary hypertension are highlighted.
  • Further investigation into lung pericyte biology is warranted to address knowledge gaps.