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Related Concept Videos

Capillary Beds01:20

Capillary Beds

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Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
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Capillary Exchange01:28

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The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
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Surface Tension, Capillary Action, and Viscosity02:57

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Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
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Capillaries and Their Types01:20

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Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists,...
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Capillary Electrophoresis: Instrumentation01:20

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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
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Capillary Electrophoresis: Applications01:30

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Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
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Updated: Jan 26, 2026

Culture of Brain Capillary Pericytes for Cytosolic Calcium Measurements and Calcium Imaging Studies
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Culture of Brain Capillary Pericytes for Cytosolic Calcium Measurements and Calcium Imaging Studies

Published on: May 27, 2020

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Cochlear Capillary Pericytes.

Martin Canis1, Mattis Bertlich2

  • 1The Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Munich, Germany.

Advances in Experimental Medicine and Biology
|April 3, 2019
PubMed
Summary
This summary is machine-generated.

Cochlear capillary pericytes, though debated, are crucial for hearing health. These cells form barriers, regulate blood flow, and aid immune responses, impacting hearing loss and cochlear inflammation.

Keywords:
Capillary pericytesCochleaCochlear blood flowCochlear blood flow regulationCochlear pathologyFluid homeostasisImmune responseStrial blood-fluid barrier

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Area of Science:

  • Oto-science
  • Neuroscience
  • Cell Biology

Background:

  • Cochlear pericytes are under-researched compared to central nervous system counterparts.
  • Debate exists on whether terminal arterioles in the cochlea are pericytes.
  • Recent focus on cochlear pericytes reveals their significant presence and diverse roles.

Purpose of the Study:

  • To elucidate the functions and significance of capillary pericytes in the mammalian cochlea.
  • To highlight the role of pericytes in cochlear physiology and pathology.

Main Methods:

  • Immunohistochemical analysis to identify pericyte subpopulations based on immune markers.
  • Functional assays to assess pericyte roles in barrier formation, blood flow regulation, and immune response.
  • Review of existing literature on cochlear pericyte research.

Main Results:

  • Cochlear capillary pericytes are abundant, with up to 1300 per mouse in the stria vascularis.
  • Pericytes differentiate into subpopulations with distinct immune markers.
  • Identified three core functions: intrastrial blood-fluid barrier formation, cochlear blood flow regulation, and immune response contribution.

Conclusions:

  • Cochlear pericytes are vital for maintaining cochlear homeostasis and function.
  • Pericyte dysfunction is implicated in various cochlear pathologies, including sudden sensorineural hearing loss and inflammation.
  • Further research into cochlear pericytes is warranted due to their critical roles.