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Survivin at a glance.

Sally P Wheatley¹, Dario C Altieri²

¹Department of Biochemistry, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK sally.wheatley@nottingham.ac.uk.

Journal of Cell Science

|April 6, 2019

Summary

This summary is machine-generated.

Survivin (BIRC5) is crucial for cell division and survival. Upregulated in most cancers, this protein is a key target for new oncotherapeutic strategies.

Keywords:

Apoptosis BIRC5 Cancer Mitosis Survivin

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Area of Science:

Molecular Biology
Cell Biology
Oncology

Background:

Survivin (BIRC5) is an evolutionarily conserved protein vital for cell division and apoptosis inhibition.
Normally expressed only in proliferating cells, survivin is upregulated in most cancers, making it a significant oncotherapeutic target.

Purpose of the Study:

To summarize current knowledge on survivin 21 years after its discovery.
To provide an overview of survivin's structure, expression, function, and interactions.
To review ongoing anti-survivin therapeutic strategies.

Main Methods:

Literature review and synthesis of existing research on survivin.
Analysis of survivin's molecular structure and cellular roles.
Compilation of data on survivin's interactome and therapeutic targeting.

Main Results:

Survivin plays a critical role in cell division and preventing cell death.
Its aberrant expression in cancer highlights its oncogenic potential.
Various anti-survivin strategies are currently under clinical investigation.

Conclusions:

Survivin remains a highly relevant target in cancer research and therapy.
Understanding survivin's complex functions and interactions is key to developing effective treatments.
Ongoing trials explore novel approaches to inhibit survivin in cancer patients.