DYNAMICS OF INDICES OF OXIDATIVE STRESS IN PATIENTS WITH THYROID GLAND SURGERY DEPENDING ON ITS FUNCTIONAL ACTIVITY

Area of Science:

• Endocrinology
• Metabolic Disorders
• Oxidative Stress Research

Background:

• Hormonal imbalances in thyroid dysfunction disrupt metabolic processes.
• Both hypothyroidism and hyperthyroidism contribute to an imbalanced prooxidant-antioxidant system, leading to oxidative stress.

Purpose of the Study:

• To investigate oxidative stress markers in patients undergoing thyroid surgery.
• To correlate oxidative stress with thyroid gland functional activity and the presence of autoimmune thyroiditis.

Main Methods:

• Assessed lipid peroxidation intensity via diene conjugates and malondialdehyde levels.
• Measured antioxidant system activity by analyzing red blood cell levels of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase.

Main Results:

• Specific patterns in lipid peroxidation and antioxidant enzyme activity were observed, varying with thyroid gland functional states.
• Distinct oxidative stress profiles were identified based on the presence or absence of autoimmune thyroiditis.

Conclusions:

• Thyroid functional status and autoimmune thyroiditis significantly influence oxidative stress markers.
• Metabolic disturbances in thyroid pathology, particularly with hormonal imbalance and autoimmune thyroiditis, result in chronic endogenous intoxication.