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    Area of Science:

    • Biomedical imaging
    • Medical physics
    • Deep learning applications

    Background:

    • Fluorescence molecular tomography (FMT) is a noninvasive in vivo imaging technique.
    • Current FMT reconstruction quality is limited by simplified linear models of photon propagation.

    Purpose of the Study:

    • To develop an advanced method for improving FMT image reconstruction quality.
    • To address the limitations of linear models in FMT.

    Main Methods:

    • An end-to-end three-dimensional deep encoder-decoder (3D-En-Decoder) network was proposed.
    • The network establishes a direct nonlinear mapping between fluorescent source distribution and boundary signal.
    • Numerical simulations and phantom experiments were conducted.

    Main Results:

    • The 3D-En-Decoder network significantly improved FMT image quality.
    • Reconstruction time was substantially reduced compared to conventional methods.
    • The proposed network fundamentally avoids reconstruction inaccuracies from simplified linear models.

    Conclusions:

    • The 3D-En-Decoder network offers a superior approach for FMT reconstruction.
    • This deep learning method enhances both accuracy and efficiency in FMT imaging.
    • The findings suggest a significant advancement for in vivo functional imaging.