Clinicopathologic features in two cases of multiple myeloma

Area of Science:

• Ophthalmology
• Oncology
• Pathology

Background:

• Multiple myeloma is a malignant plasma cell neoplasm.
• Ocular manifestations in multiple myeloma are diverse and can impact vision.
• Understanding the ocular pathology is crucial for patient management.

Observation:

• Ocular examination revealed opaque ciliary body cysts, ciliochoroidal effusion, and retinal hemorrhages.
• Retinal pigment epithelium and sensory retina detachment were noted.
• A recanalized thrombus in a retrolaminar vein and pars plana cyst continuity with retinal detachment were observed in one case.

Findings:

• Pathologic analysis identified immunoprotein deposits in the anterior chamber, ciliary body, choroid, and subretinal spaces.
• Opaque ciliary body cysts were a significant pathological finding.
• The presence of immunoprotein suggests a direct link between systemic disease and ocular pathology.

Implications:

• These findings highlight the severe ocular complications associated with multiple myeloma.
• Immunoprotein deposition may contribute to the pathogenesis of various ocular abnormalities.
• Further research into the mechanisms of ocular involvement can guide therapeutic strategies.