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Updated: Jan 26, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
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Egg white coated alginate nanoparticles with electron sprayer for potential anticancer application.
Jianhua Zhang1, Jun Huang2, Keqing Huang2
1School of Materials Science and Engineering, Xihua University, Chengdu 610039, PR China; Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen 518057, PR China.
International Journal of Pharmaceutics
|April 19, 2019
Summary
Egg white/sodium alginate nanoparticles loaded with paclitaxel show potential for cancer therapy. These biocompatible nanoparticles exhibit good drug release and effectively inhibit colorectal cancer cells in vitro.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Therapy
Background:
- Developing effective cancer therapies remains a critical challenge.
- Biomimetic strategies offer novel approaches for drug delivery.
- Egg white and sodium alginate present biocompatible materials for nanoparticle formulation.
Purpose of the Study:
- To develop paclitaxel-loaded egg white/sodium alginate nanoparticles using an electronic spray method.
- To evaluate the characteristics, drug release, biocompatibility, and anti-cancer efficacy of these nanoparticles.
- To explore a biomimetic strategy for enhanced cancer treatment.
Main Methods:
- Nanoparticle preparation via electronic spray method.
- Characterization using transmission electron microscopy and particle size analysis.
- Drug release studies using high-performance liquid chromatography (HPLC).
- In vitro cytotoxicity and cellular interaction assessed by MTT assay, live/dead staining, and laser scanning confocal microscopy.
Main Results:
- Successfully prepared nanoparticles with good particle size distribution and regular morphology.
- Demonstrated favorable drug release profiles.
- Exhibited good biocompatibility and effective in vitro inhibition of CT26 colorectal cancer cells.
- Confirmed nanoparticle interaction with cancer cells.
Conclusions:
- Egg white coated sodium alginate nanoparticles loaded with paclitaxel (PTX) are biocompatible.
- These nanoparticles show promising potential for application in cancer therapy due to their efficacy against colorectal cancer cells.
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