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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: Jan 25, 2026

Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues
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Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues

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Heterogeneity in Adipose Stem Cells.

Elio A Prieto González1,2

  • 1Centre for Advanced Studies in Humanities and Health Sciences, Interamerican Open University, Buenos Aires, Argentina. Elio.Prietto@vaneduc.edu.ar.

Advances in Experimental Medicine and Biology
|April 25, 2019
PubMed
Summary
This summary is machine-generated.

Adipose stem cells (ASCs) exhibit significant heterogeneity due to donor and processing factors. Understanding this variability is crucial for standardizing ASCs-based regenerative medicine and improving therapeutic outcomes.

Keywords:
Adipose stem cellAdipose tissue depotGene expression analysisHeterogeneityImmunophenotypeMesenchymalStemnessStromal vascular fractionXeno-free

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Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Tissue Engineering

Background:

  • Adipose stem cells (ASCs) are key for tissue regeneration.
  • ASCs display heterogeneity influenced by donor, isolation, and culture conditions.

Purpose of the Study:

  • To highlight the impact of ASCs heterogeneity on regenerative procedures.
  • To emphasize the need for standardizing ASCs-based therapies.

Main Methods:

  • Review of factors contributing to ASCs heterogeneity.
  • Analysis of phenotypic features affected by heterogeneity (proliferation, differentiation, immunophenotype, secretome).

Main Results:

  • Donor age, sex, BMI, isolation method, sampling site, and culture conditions significantly affect ASCs.
  • Heterogeneity impacts ASCs' therapeutic potential through direct effects and paracrine signaling.

Conclusions:

  • Standardizing ASCs procedures requires understanding heterogeneity sources.
  • Future research should explore homogeneous ASCs, cell-recipient interactions, epigenetics, and metabolomics.