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Updated: Jan 25, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids
Tanaya Bose1, Vaijayanti A Kumar2
1CSIR-National Chemical Laboratory, Pune, Maharashtra, India.
Abstract:
Glycol carbamate nucleic acid (GCNA) oligomers can be produced from activated carbonate monomers. The synthesized monomers can be very conveniently characterized employing analytical tools like NMR and HR-MS. Moreover, the activated carbonate monomers do not require coupling agents, and hence excess monomers can be recovered at the end of each coupling. Here we illustrate the synthesis of activated glycol carbonate monomers and their subsequent application in synthesis of carbamate oligomers.
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