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Evaluation of Kagocel Genotoxicity.
A K Zhanataev1, T G Borovskaya2, B S Shcherbakova3
1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. zhanataev@academpharm.ru.
Bulletin of Experimental Biology and Medicine
|April 26, 2019
Summary
The antiviral drug Kagocel was tested for genotoxicity. Kagocel did not induce gene mutations or chromosomal damage in various assays, indicating no genotoxic activity.
Area of Science:
- Pharmacology
- Toxicology
- Genetics
Background:
- Antiviral drugs require rigorous safety evaluation.
- Genotoxicity testing is crucial for assessing drug safety.
- Kagocel is an antiviral medication whose genotoxic potential needs to be understood.
Purpose of the Study:
- To evaluate the genotoxic activity of the antiviral drug Kagocel.
- To determine if Kagocel induces gene mutations or chromosomal damage.
Main Methods:
- Bacterial reverse mutation assay (Ames test) using Salmonella typhimurium strains and E. coli.
- In vivo chromosomal aberration test in mouse bone marrow cells.
- In vivo DNA comet assay in mouse testicular cells.
Main Results:
- Kagocel did not induce gene mutations in S. typhimurium or E. coli strains at tested concentrations.
- No significant increase in chromosomal aberrations was observed in mouse bone marrow cells.
- No significant increase in DNA breaks was detected in mouse testicular cells.
Conclusions:
- Kagocel exhibits no genotoxic activity in the studied dose range.
- The findings support the safety profile of Kagocel regarding genetic toxicity.
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