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Evaluation of Kagocel Genotoxicity.

A K Zhanataev1, T G Borovskaya2, B S Shcherbakova3

  • 1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. zhanataev@academpharm.ru.

Bulletin of Experimental Biology and Medicine
|April 26, 2019
PubMed
Summary

The antiviral drug Kagocel was tested for genotoxicity. Kagocel did not induce gene mutations or chromosomal damage in various assays, indicating no genotoxic activity.

Keywords:
Ames testDNA comet assayKagocelchromosome aberrationsgenotoxicity

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Area of Science:

  • Pharmacology
  • Toxicology
  • Genetics

Background:

  • Antiviral drugs require rigorous safety evaluation.
  • Genotoxicity testing is crucial for assessing drug safety.
  • Kagocel is an antiviral medication whose genotoxic potential needs to be understood.

Purpose of the Study:

  • To evaluate the genotoxic activity of the antiviral drug Kagocel.
  • To determine if Kagocel induces gene mutations or chromosomal damage.

Main Methods:

  • Bacterial reverse mutation assay (Ames test) using Salmonella typhimurium strains and E. coli.
  • In vivo chromosomal aberration test in mouse bone marrow cells.
  • In vivo DNA comet assay in mouse testicular cells.

Main Results:

  • Kagocel did not induce gene mutations in S. typhimurium or E. coli strains at tested concentrations.
  • No significant increase in chromosomal aberrations was observed in mouse bone marrow cells.
  • No significant increase in DNA breaks was detected in mouse testicular cells.

Conclusions:

  • Kagocel exhibits no genotoxic activity in the studied dose range.
  • The findings support the safety profile of Kagocel regarding genetic toxicity.