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Updated: Jan 25, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression
Akira Kudo1,2
1International Frontier, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan. akudo@bio.titech.ac.jp.
Abstract:
Although many studies have described the role of periostin in various diseases, the functions of periostin derived from alternative splicing and proteinase cleavage at its C-terminus remain unknown. Further experiments investigating the periostin structures that are relevant to diseases are essential for an in-depth understanding of their functions, which would accelerate their clinical applications by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress .
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