Related Experiment Video
Updated: Jan 25, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Structure and function of eTudor domain containing TDRD proteins.
Bing Gan1, Sizhuo Chen1, Huan Liu1
1a Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences , Central China Normal University , Wuhan , PR China.
Tudor domain-containing (TDRD) proteins bind PIWI proteins, crucial for piRNA biogenesis and germ cell development. Understanding their distinct binding mechanisms aids in disease research and therapeutic development.
Area of Science:
- Molecular Biology
- Genetics
Background:
- Tudor domain-containing (TDRD) proteins are evolutionarily conserved and play vital roles in biological processes.
- A key function involves recognizing P-element-induced wimpy testis (PIWI) proteins via extended Tudor (eTudor) domains.
Purpose of the Study:
- To review recent advancements in TDRD protein research.
- To discuss the molecular mechanisms underlying the selective binding of eTudor domains to PIWI proteins.
Main Methods:
- Review of existing binding and structural data.
- Analysis of molecular mechanisms for TDRD-PIWI interactions.
Main Results:
- TDRD proteins' eTudor domains exhibit differential binding selectivity towards PIWI proteins.
- This selectivity is critical for piRNA biogenesis and germ cell development.
Conclusions:
- Understanding TDRD-PIWI binding differences clarifies their functional distinctions.
- This knowledge is valuable for developing targeted therapeutics for diseases associated with TDRD dysfunction.
Related Concept Videos
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Structural Protein Function
Mechanical Protein Functions
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
Conservation of Protein Domains

