Related Experiment Video
Updated: Jan 25, 2026

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
Published on: May 30, 2025
Multidisciplinary Therapy of Esophageal Cancer
Matthew R Egyud1, Jennifer F Tseng2, Kei Suzuki3
1Department of Surgery, Boston University School of Medicine, 88 East Newton Street, Collamore C-500, Boston, MA 02118, USA.
Abstract:
Multimodality therapy is the standard of care for locoregional esophageal cancers (greater than clinical T3 or Nþ), including Siewert type 1 and 2 gastroesophageal junction tumors. Induction regimen, chemotherapy only or chemoradiation, is an area of controversy and often institution-specific, as neither has shown to be superior. Response to induction therapy is an important prognostic marker. For esophageal squamous cell carcinoma, it may be acceptable to observe clinical complete responders after chemoradiotherapy and perform salvage esophagectomy for recurrent disease. Clinical T2N0 esophageal cancer presents a unique challenge given its inaccuracy in clinical staging; management of this particular subset is controversial.
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