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Normative Data for Retinal-Layer Thickness Maps Generated by Spectral-Domain OCT in a White Population
Alessandro Invernizzi1, Marco Pellegrini2, Alessandra Acquistapace2
1Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco," Luigi Sacco Hospital, University of Milan, Milan, Italy; Save Sight Institute, Sydney Eye Hospital, University of Sydney, Sydney, New South Wales, Australia.
Ophthalmology. Retina
|May 4, 2019
Summary
This study provides normative retinal layer thickness values for a healthy white population using spectral-domain optical coherence tomography (SD-OCT). Retinal layer thickness varies with age, sex, and axial length (AXL).
Area of Science:
- Ophthalmology
- Retinal Imaging
- Biometry
Background:
- Accurate normative data for retinal layer thickness is crucial for diagnosing and monitoring retinal diseases.
- Spectral-domain optical coherence tomography (SD-OCT) allows for precise segmentation and measurement of individual retinal layers.
- Factors such as age, sex, and axial length (AXL) may influence retinal layer thickness.
Purpose of the Study:
- To establish a dataset of normative Early Treatment Diabetic Retinopathy Study (ETDRS) thickness map values for automatically segmented retinal layers using SD-OCT in a healthy white population.
- To investigate the influence of age, sex, and axial length (AXL) on these normative retinal layer thickness values.
Main Methods:
- A cross-sectional study involving 200 healthy adult emmetropic white subjects.
- SD-OCT scans (30 x 25-degree volume) centered on the fovea were acquired.
- Automatic segmentation of retinal layers was performed, and mean thickness values for 9 ETDRS sectors were calculated. Statistical analysis tested the effects of age, sex, and AXL on central subfield, inner ring (IR), and outer ring (OR) thicknesses.
Main Results:
- Normative thickness values for individual retinal layers were collected.
- Full retinal thickness was greater in males across all subfields (P < 0.05).
- Ganglion cell layer, inner plexiform layer, inner nuclear layer, and outer nuclear layer thicknesses showed significant correlations with AXL and/or sex in specific ETDRS sectors. Nerve fiber layer and retinal pigment epithelium thickness were not significantly affected by the studied variables. Repeatability measurements showed high intraclass correlation coefficients (0.872–0.990).
Conclusions:
- This study provides normative retinal layer thickness values for a large white population, segmented automatically by SD-OCT.
- Retinal layer thickness is demonstrably influenced by sex and axial length, with variations dependent on the specific ETDRS map sector analyzed.
- These findings contribute valuable reference data for clinical interpretation and research involving retinal imaging.
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