Related Experiment Video
Updated: Jan 25, 2026
09:30
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
20.1K
Physiological and pathological skeletal muscle T1 changes quantified using a fast inversion-recovery radial NMR
Benjamin Marty1,2, Pierre G Carlier3,4
1Institute of Myology, Neuromuscular Investigation Center, NMR Laboratory, Paris, France. b.marty@institut-myologie.org.
Scientific Reports
|May 4, 2019
Summary
Global T1 in skeletal muscle is sensitive to sex, muscle group, and exercise. T1 variations indicate tissue changes in muscle pathologies like Becker muscular dystrophy and inclusion body myositis.
Area of Science:
- Biomedical Engineering
- Radiology
- Musculoskeletal Imaging
Background:
- Skeletal muscle T1 mapping is crucial for understanding tissue physiology and pathology.
- Previous studies have explored T1 variations, but comprehensive analysis across physiological and pathological states is needed.
Purpose of the Study:
- To investigate skeletal muscle global T1 response to physiological factors (sex, age, exercise) and pathological conditions (BMD, IBM).
- To correlate global T1 with other MRI parameters like T2 and fat content.
Main Methods:
- Utilized an inversion-recovery radial T1 mapping sequence for skeletal muscle global T1 measurement.
- Included 35 healthy volunteers and 14 patients with muscular dystrophy (BMD) or inclusion body myositis (IBM).
- Measured intramuscular fat content (3-point Dixon) and global T2/water T2 (multi-spin-echo).
Main Results:
- Global T1 was not affected by age in healthy individuals but varied significantly with sex and muscle group.
- Exercise induced a 7.7% increase in global T1 in recruited muscles, correlating with T2H2O changes (R=0.91).
- Fat-infiltrated muscles showed reduced global T1; IBM patients had higher global T1 than BMD patients when fat fraction was considered.
Conclusions:
- Skeletal muscle global T1 is a sensitive biomarker for physiological changes and pathological alterations.
- T1 mapping provides valuable insights into muscle tissue characteristics in health and disease.
Related Concept Videos
01:48Classification of Skeletal Muscle Fibers
59.4K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.4K
01:24Muscle Recovery and Fatigue
4.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.1K
01:29Relaxation of Skeletal Muscles
5.7K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.7K
01:15Overview of Skeletal Muscle
14.4K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
14.4K
00:55Skeletal Muscle Anatomy
92.7K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
92.7K
01:28Disorders of the Skeletal Muscle
1.7K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.7K