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Ultrafast polarization bio-imaging based on coherent detection and time-stretch techniques
Lu Song1, Yuanhua Feng2, Xiaojie Guo1
1Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.
Biomedical Optics Express
|May 9, 2019
Summary
This study introduces ultrafast polarization bio-imaging, achieving a record 100 MHz line scanning rate. This breakthrough enables rapid, label-free analysis of biological samples
Area of Science:
- Biomedical Optics
- Imaging Science
- Biophysics
Background:
- Optical polarization imaging offers label-free, non-invasive analysis of biological samples, revealing properties like birefringence and optical rotation.
- Existing polarization imaging methods are limited by slow detector frame rates, hindering real-time biological studies.
Purpose of the Study:
- To develop an ultrafast polarization bio-imaging technique.
- To overcome the speed limitations of conventional polarization imaging methods.
- To enable high-speed, label-free imaging of polarization-sensitive properties in biological tissues.
Main Methods:
- Combined optical coherent detection of orthogonal polarizations with optical time-stretch imaging.
- Achieved a record line scanning rate of 100 MHz without signal averaging.
- Developed a system for retrieving Jones matrix and polarization-sensitive information.
Main Results:
- Demonstrated ultrafast polarization bio-imaging at 100 MHz.
- Successfully imaged three different biological sample slices.
- Retrieved detailed polarization information, including birefringence and diattenuation.
Conclusions:
- The developed technique offers unprecedented speed for polarization imaging in biological applications.
- This method facilitates label-free, non-invasive analysis of dynamic polarization phenomena in living samples.
- Potential applications include advanced biomedical research and real-time studies of biological processes.
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