Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

1.5K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.5K
Three Developmental Domains01:29

Three Developmental Domains

1.0K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.0K
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

252
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
252
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

287
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
287
In Vitro Fertilization01:24

In Vitro Fertilization

924
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
924
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

16.1K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind the Litter: The Critical Role of Intralitter Variables in Reproductive and Developmental Toxicology Research.

Birth defects research·2026
Same author

Benzene-induced growth restriction and compensatory rebound in mouse fetuses and placentas.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same author

Triphenyl phosphate induces coordinated DNA methylation and gene expression changes in aquatic embryonic cells.

Environmental epigenetics·2026
Same author

Acetaminophen Use During Pregnancy and Neurodevelopmental Risk: Biological Plausibility.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2025
Same author

Systematic Review and Meta-Analysis: Acetaminophen Use During Pregnancy and the Risk of Neurodevelopmental Disorders in Childhood.

Journal of the American Academy of Child and Adolescent Psychiatry·2025
Same author

Commercialization of cell and gene therapy in Canada: Current landscape, challenges and opportunities.

Drug discovery today·2025
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

7.2K

In Vitro Models in Developmental Toxicology.

Louise M Winn1,2

  • 1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. winnl@queensu.ca.

Methods in Molecular Biology (Clifton, N.J.)
|May 10, 2019
PubMed
Summary
This summary is machine-generated.

In vitro models assess developmental toxicity from drugs and chemicals, aiding early screening and understanding toxic mechanisms. These methods support the 3Rs principles: replace, reduce, and refine.

Keywords:
Cell cultureDevelopmentIn vitro methodsOrgan cultureTissue cultureToxicantWhole embryo culture

More Related Videos

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.6K
Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities
11:00

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

4.8K

Related Experiment Videos

Last Updated: Jan 25, 2026

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

7.2K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.6K
Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities
11:00

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

4.8K

Area of Science:

  • Toxicology
  • Developmental Biology
  • In Vitro Models

Background:

  • Exogenous compounds like drugs and environmental chemicals pose risks to development.
  • Assessing developmental toxicity is crucial for understanding chemical safety.
  • In vitro models offer alternatives to traditional animal testing.

Purpose of the Study:

  • To review various in vitro models for assessing developmental toxicity.
  • To highlight the advantages and disadvantages of different models.
  • To emphasize the role of these models in chemical screening and mechanistic studies.

Main Methods:

  • Cultured cells (Chapters 3-6)
  • Organ and tissue cultures (Chapters 7-8)
  • Whole embryo cultures (Chapters 13-15)

Main Results:

  • In vitro models provide diverse approaches to developmental toxicity testing.
  • These models align with the 3Rs principles (replace, reduce, refine).
  • They facilitate early chemical screening and elucidate toxicity mechanisms.

Conclusions:

  • In vitro models are valuable tools for assessing developmental toxicity.
  • These models contribute to a better understanding of chemical impacts on development.
  • Their application supports safer chemical development and risk assessment.