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Determining the Ice-binding Planes of Antifreeze Proteins by Fluorescence-based Ice Plane Affinity
Published on: January 15, 2014
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[Diffuse plane xanthomas associated with mycosis fungoides].
Julia K Winkler1, Jochen Hoffmann2, Alexander Enk2
1Universitäts-Hautklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland. Julia.Winkler@med.uni-heidelberg.de.
Summary
Dystrophic xanthomas, typically linked to lipid issues, can signal underlying cancers. This case highlights normolipemic xanthomas as an early sign of mycosis fungoides, a rare cutaneous T-cell lymphoma.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Cutaneous xanthomas are skin lesions associated with lipid disorders, inflammation, or malignancy.
- Dystrophic xanthomas, specifically, can be linked to myeloproliferative neoplasms.
- Mycosis fungoides is the most common type of cutaneous T-cell lymphoma.
Observation:
- A normolipemic patient presented with cutaneous xanthomas.
- The patient was subsequently diagnosed with mycosis fungoides.
Findings:
- This case represents a rare presentation of cutaneous xanthomas in a normolipemic individual.
- Mycosis fungoides, the most common cutaneous T-cell lymphoma, can manifest with dystrophic xanthomas.
Implications:
- Highlights the importance of investigating cutaneous xanthomas even in normolipemic patients.
- Underscores the association between dystrophic xanthomas and mycosis fungoides, aiding in earlier diagnosis.
- Contributes to the understanding of rare dermatological manifestations of hematologic malignancies.
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