Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Group Therapy01:26

Group Therapy

391
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
391
Psychodynamic Therapy01:29

Psychodynamic Therapy

542
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
542
Humanistic Therapy01:24

Humanistic Therapy

342
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
342
Modeling in Therapy01:26

Modeling in Therapy

402
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual AI models for gamma knife radiosurgery in craniopharyngioma: prescription dose modeling and outcome risk prediction.

Journal of neuro-oncology·2026
Same author

Machine learning prediction of local control after Gamma Knife radiosurgery to post-resection cavities from brain metastases: a proof-of-concept study.

Journal of neuro-oncology·2026
Same author

Therapeutic Hybrid Intelligence with Neural and Knowledge-based Expert Reasoning for SRS (THINKERS): an AI model for GBM.

Journal of neuro-oncology·2026
Same author

Dose De-escalation in Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients on Concurrent Immunotherapy or Targeted Therapy: A Multicenter Experience.

Neurosurgery·2026
Same author

Beyond tumor control: symptom trajectories and hearing outcomes after contemporary Gamma Knife radiosurgery for vestibular schwannoma.

Journal of neuro-oncology·2026
Same author

Therapeutic Hybrid Intelligence with Neural and Knowledge-based Expert Reasoning for SRS (THINKERS): a mixture-of-experts AI model for vestibular schwannoma.

Journal of neuro-oncology·2026

Related Experiment Video

Updated: Jan 24, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.9K

Targeted Therapies for Brain Metastases.

Ajay Niranjan1, L Dade Lunsford2, Manmeet S Ahluwalia3

  • 1Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA, niraax@UPMC.EDU.

Progress in Neurological Surgery
|May 17, 2019
PubMed
Summary

New medical therapies, including targeted tyrosine kinase inhibitors and immunotherapies, are improving outcomes for brain metastases from lung, breast, and melanoma cancers. These treatments offer new hope for patients with both brain and widespread disease.

More Related Videos

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

11.6K
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

6.4K

Related Experiment Videos

Last Updated: Jan 24, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.9K
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

11.6K
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
07:17

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

6.4K

Area of Science:

  • Neuro-oncology
  • Cancer Metastasis
  • Pharmacology

Background:

  • Brain metastases are common in lung cancer, breast cancer, and melanoma.
  • Traditional treatments include surgery and radiation therapy.
  • The role of medical therapies for brain metastases was historically limited.

Purpose of the Study:

  • To review advancements in medical therapies for brain metastases.
  • To highlight the efficacy of molecularly targeted agents and immunotherapies.
  • To discuss the improved understanding of drug penetration across the blood-brain barrier.

Main Methods:

  • Review of recent literature on brain metastases management.
  • Analysis of clinical data for targeted therapies and immunotherapies.
  • Discussion of molecular drivers and blood-brain barrier penetration.

Main Results:

  • Molecular targeted tyrosine kinase inhibitors show effectiveness in brain metastases with specific mutations.
  • Immunotherapies have demonstrated efficacy in managing brain metastases.
  • These agents are effective for both intracranial and extracranial disease.

Conclusions:

  • Medical therapies have significantly advanced the treatment of brain metastases.
  • Targeted therapies and immunotherapies represent a paradigm shift in managing these complex cases.
  • Further research is ongoing to optimize treatment strategies.