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Related Concept Videos

Guidelines for Nursing Documentation II01:26

Guidelines for Nursing Documentation II

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Effective documentation is an integral part of nursing practice. Here are some essential guidelines to follow when documenting patient care:
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Guidelines for Sketching a Curve01:23

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Curve sketching is a systematic method for understanding the overall behavior of a function by analyzing its key mathematical features. A function defines a curve on the coordinate plane, where the horizontal axis represents the input variable and the vertical axis represents the output. The process begins by determining the domain, which specifies the set of input values for which the function is defined and establishes the horizontal extent of the graph.Intercepts with the horizontal and...
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Guidelines for Nursing Documentation I01:30

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Quality documentation and reporting share essential characteristics that ensure they are practical and valuable resources for those who use them. These characteristics are:
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A Preclinical Murine Model of Hepatic Metastases
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Guidelines for Multiple Brain Metastases Radiosurgery.

Ajay Niranjan1, Edward Monaco2, John Flickinger3

  • 1Departments of Neurological Surgery and Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, niraax@UPMC.EDU.

Progress in Neurological Surgery
|May 17, 2019
PubMed
Summary
This summary is machine-generated.

Stereotactic radiosurgery (SRS) effectively treats multiple brain metastases, improving outcomes and reducing toxicity compared to whole-brain radiation therapy (WBRT). Current practice favors SRS for larger tumor volumes, even with numerous metastases.

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Area of Science:

  • Oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Stereotactic radiosurgery (SRS) is a recognized treatment for multiple brain metastases.
  • Studies over three decades demonstrate SRS superiority over whole-brain radiation therapy (WBRT) in improving outcomes and reducing toxicity.
  • Clinical expertise suggests intracranial tumor volume, not metastasis count, correlates with patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of SRS in treating multiple brain metastases.
  • To highlight the shift from WBRT to SRS in clinical practice for brain metastases management.
  • To underscore the role of tumor volume in treatment decisions for SRS.

Main Methods:

  • Review of scientific literature and expert opinion surveys.
  • Analysis of treatment protocols for multiple brain metastases.
  • Comparison of SRS versus WBRT outcomes and toxicity profiles.

Main Results:

  • SRS improves outcomes and reduces toxicity compared to WBRT for multiple brain metastases.
  • Intracranial tumor volume is a key factor in determining treatment success, more so than the number of metastases.
  • SRS is increasingly used alone, even for patients with 10 or more metastases and cumulative tumor volumes up to 25 cm³.

Conclusions:

  • SRS is an effective and preferred treatment for multiple brain metastases.
  • Treatment decisions should prioritize total intracranial tumor volume over metastasis count.
  • Modern oncologic therapies support the expanded use of SRS for extensive brain metastases.