Stereotactic Radiosurgery for Low-Grade Gliomas.

Area of Science:

• Neurosurgery
• Radiation Oncology
• Oncology

Background:

• Low-grade gliomas are a diverse group of brain tumors requiring individualized treatment.
• Treatment goals focus on extending survival and minimizing patient morbidity.
• Standard treatments include surgical resection, radiotherapy, and chemotherapy, with strategy tailored to tumor characteristics.

Purpose of the Study:

• To evaluate the safety and efficacy of stereotactic radiosurgery (SRS) for managing low-grade gliomas.
• To identify patient subgroups who are ideal candidates for SRS treatment.
• To highlight the role of SRS within multimodal treatment strategies for specific glioma types.

Main Methods:

• Review of recent reports and clinical data on stereotactic radiosurgery (SRS) for low-grade gliomas.
• Analysis of treatment outcomes, including tumor control and patient survival.
• Identification of criteria for patient selection for radiosurgery.

Main Results:

• Stereotactic radiosurgery (SRS) has demonstrated safety and effectiveness in controlling tumor progression.
• SRS improves survival rates for patients with low-grade gliomas.
• Patients with progressive, pilocytic, or grade 2 fibrillary astrocytomas in critical/deep brain locations are suitable for SRS.

Conclusions:

• Stereotactic radiosurgery (SRS) is a safe and promising therapeutic option for progressive, recurrent, or unresectable pilocytic or WHO grade 2 fibrillary astrocytomas.
• Gamma Knife radiosurgery is increasingly recognized as a valuable tool in managing low-grade gliomas.
• SRS can be effectively integrated into multimodal treatment plans for selected low-grade glioma patients.