[SOME PECULIARITIES OF SYPHILIS MORPHOLOGY AND PATHOLOGY (REVIEW)]

The aim of the research was to study the pathomorphosis of syphilis under modern conditions. The morbidity, clinical and epidemiological peculiarities of syphilis were analyzed both domestically (in Ukraine) and internationally. It has been established that in the pattern of syphilis morbidity, latent forms vary between 20% and 40%. Latent syphilis is detected in almost a half of the elderly patients. There has been a marked increase in the incidence of syphilis among homosexualists, prostitutes, alcoholics and drug addicts. In Ukraine from 2008 to 2014 there was a general decrease in the incidence of all forms of syphilis by 2.5 times, but the disease patterns are also changing - the number of latent diseases, late and unspecified forms with particular damage to the nervous system, visceral organs significantly increase. In examining the immunogenetic features of syphilis in the Eastern region of Ukraine, types a, b, c, d, g, i, p of the tp gene were found. Five types of arp T. pallidum gene were identified. The main aim of T. Pallidum detection in the samples is PCR, during late and latent forms of TPHA. Penicillin drugs remain the main plank of the therapy. Thus, in the case of syphilis, nosological entity and clinical disease evidence have been blurred. To ensure the prompt diagnosis and treatment of the disease, it is necessary to consider serology, immunogenetic peculiarities, neurological, and therapeutic status of the patient.