Immune Responses of Mammals and Plants to Chitin-Containing Pathogens

Chitin-containing organisms, such as fungi and arthropods, use chitin as a structural component to protect themselves from harsh environmental conditions. Hosts such as mammals and plants, however, sense chitin to initiate innate and adaptive immunity and exclude chitin-containing organisms. A number of protein factors are then expressed, and several signaling pathways are triggered. In this chapter, we focus on the responses and signal transduction pathways that are activated in mammals and plants upon invasion by chitin-containing organisms. As host chitinases play important roles in the glycolytic processing of chitin, which is then recognized by pattern-recognition receptors, we also pay special attention to the chitinases that are involved in immune recognition.