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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Psychodynamic Therapy01:29

Psychodynamic Therapy

542
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
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Related Experiment Video

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Ultrasound Cyclo Plasty in Eyes with Glaucoma
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The future of canine glaucoma therapy.

András M Komáromy1, Dineli Bras2, Douglas W Esson3

  • 1College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Veterinary Ophthalmology
|May 21, 2019
PubMed
Summary

Canine glaucoma causes irreversible vision loss in dogs, with no current cure. Research is urgently needed for better treatments, focusing on surgical options and novel therapies like gene and stem cell treatments.

Keywords:
aqueous humorcanineglaucomaintraocular pressureoptic nervesurgery

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Area of Science:

  • Veterinary Ophthalmology
  • Canine Health
  • Ocular Disease Research

Background:

  • Canine glaucoma involves increased intraocular pressure (IOP), leading to optic neuropathy and irreversible vision loss.
  • It is a significant cause of blindness in dogs, with current treatments often insufficient.
  • There is a critical need for improved, affordable therapies for canine glaucoma.

Purpose of the Study:

  • To summarize research strategies for developing more effective canine glaucoma therapies.
  • To identify key areas for advancement in managing canine glaucoma.
  • To address the urgent need for better treatment options for affected dogs.

Main Methods:

  • Summarized discussions from a Think Tank and Consortium focused on canine glaucoma.
  • Organized and funded by the American College of Veterinary Ophthalmologists Vision for Animals Foundation (ACVO-VAF).
  • Synthesized expert recommendations for future research directions.

Main Results:

  • Identified five key areas for research: disease mechanisms, early diagnosis, medical treatment optimization, new surgical therapies, and novel strategies (gene/stem cell therapy, neuroprotection, neuroregeneration).
  • Emphasized the need for increased research funding dedicated to canine glaucoma.
  • Highlighted surgical options as a promising near-term approach.

Conclusions:

  • Current treatments for canine glaucoma are limited, necessitating urgent research.
  • A multi-faceted research approach is recommended, including understanding disease mechanisms and exploring advanced therapies.
  • Increased funding is crucial to accelerate the development of effective treatments for canine glaucoma.