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LncRNA Erbb4-IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating miR-145

Yan Zhang1, Li Zhang2, Ruimin Wang3

  • 1Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.

Journal of Cellular Biochemistry
|May 24, 2019
PubMed

Insights

Long non-coding RNA Erbb4-IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating microRNA-145 (miR-145). This lncRNA is upregulated in ESCC tumors and plasma, correlating with disease progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Erbb4-IR is a novel long non-coding RNA (lncRNA) implicated in renal injury.
  • Its role in esophageal squamous cell carcinoma (ESCC) remains largely unexplored.

Purpose of the Study:

  • To investigate the function and mechanism of Erbb4-IR in the development of ESCC.
  • To explore the relationship between Erbb4-IR and microRNA-145 (miR-145) in ESCC.

Main Methods:

  • Analysis of Erbb4-IR expression in ESCC tumor tissues and plasma.
  • Investigation of the correlation between Erbb4-IR and miR-145 expression.
  • In vitro experiments assessing the effects of Erbb4-IR and miR-145 overexpression on ESCC cell proliferation and apoptosis.

Main Results:

  • Erbb4-IR was significantly upregulated in ESCC tumor tissues and plasma, correlating with tumor expression levels.
  • miR-145 was downregulated in ESCC tissues and inversely correlated with Erbb4-IR.
  • Erbb4-IR overexpression increased ESCC cell proliferation and decreased apoptosis, while downregulating miR-145.
  • miR-145 overexpression counteracted the effects of Erbb4-IR.

Conclusions:

  • lncRNA Erbb4-IR promotes ESCC progression, potentially by suppressing miR-145.
  • Erbb4-IR may serve as a potential biomarker and therapeutic target for ESCC.
Keywords:
esophageal squamous cell carcinomalncRNA Erbb4-IRmiR-145

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