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Updated: Jan 24, 2026

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A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
Published on: July 1, 2020
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Using metro lines for integration of nucleotide metabolic pathways
Rebecca K Y Lee1, Bernard Y N Ng2, Daisy M H Chen3
1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, HKSAR.
Summary
Students struggle with biochemical pathway integration. AG City uses a metro map analogy to visualize nucleotide metabolism pathways, enhancing understanding of molecular connections.
Area of Science:
- Biochemistry Education
- Metabolic Pathway Visualization
- Molecular Biology Learning
Background:
- Students often struggle to grasp the interconnectedness of metabolic pathways due to traditional one-by-one teaching methods.
- Existing online resources for energy metabolism typically focus on individual pathways, neglecting their integration.
- Understanding nucleotide metabolism and its links to other pathways is crucial for biochemistry students.
Purpose of the Study:
- To develop an engaging self-learning tool, "AG City", to improve student comprehension of nucleotide metabolism.
- To visually represent the integration of various metabolic pathways using an innovative concept map.
- To enhance students' ability to identify and link key molecules across different biochemical pathways.
Main Methods:
- Designed a novel concept map utilizing a metro map metaphor for visualizing metabolic pathways.
- Implemented interactive elements including navigation, animations, and narrations to explain major pathways as "railway lines".
- Represented key molecules as "railway stations" to facilitate recognition of commonalities across pathways.
Main Results:
- The metro map concept effectively provides an overview of metabolic pathways and their integration.
- Interactive features enhance student engagement and understanding of nucleotide metabolism.
- Students can readily identify shared molecules (stations) to connect different metabolic concepts.
Conclusions:
- The "AG City" tool, using a metro map analogy, successfully addresses the challenge of teaching metabolic pathway integration.
- This interactive approach fosters a deeper understanding of nucleotide metabolism and its connections.
- The courseware, developed with Articulate Storyline, offers a valuable resource for biochemistry education.
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