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Updated: Jan 24, 2026
02:33
Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
Published on: May 17, 2024
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Staircase-pattern neonatal line in human deciduous teeth is associated with tooth type
Jaana Hurnanen1, Matti Sillanpää2, Marja-Leena Mattila3
1Departments of Oral Pathology, University of Turku, Finland.
Archives of Oral Biology
|June 1, 2019
Summary
The staircase (Sc) pattern in the neonatal line (NNL) of deciduous teeth varies by tooth type and is linked to prenatal crown enamel ratio. This finding aids research into ameloblast impairment and NNL width factors.
Area of Science:
- Developmental Biology
- Paleodontology
- Enamel Microstructure
Background:
- The staircase (Sc) pattern in enamel microstructure signifies impaired ameloblast function.
- This pattern is observed in the neonatal line (NNL), a marker of birth in deciduous teeth.
Purpose of the Study:
- To determine the prevalence of Sc in the NNL across different deciduous tooth types.
- To explore potential associations between Sc prevalence and perinatal factors.
Main Methods:
- Examined 88 teeth from a prospective population cohort for Sc in the NNL.
- Utilized linear polarized transmitted light microscopy.
- Analyzed Sc prevalence in relation to tooth type, delivery duration/mode, and maternal pain medication during labor.
Main Results:
- Sc prevalence in the NNL showed significant differences among deciduous tooth types (p < 0.0001).
- Higher Sc prevalence correlated significantly with a greater prenatal to total crown enamel ratio (p < 0.001).
- No significant associations were found between Sc prevalence and delivery duration, mode, or pain medication used.
Conclusions:
- NNL location within tooth enamel significantly influences microstructural changes.
- Deciduous canines, with minimal Sc, are suitable for studies on NNL width factors.
- Sc prevalence variations in deciduous molars may help investigate physiological stressors impacting ameloblast function.
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