Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

16.0K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.0K
Histone Modification02:32

Histone Modification

4.4K
4.4K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.4K
Behavior Modification01:21

Behavior Modification

589
Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
589
Protein Modifications in the RER01:26

Protein Modifications in the RER

7.0K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
7.0K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Auditory-Motor Mechanisms of the Lombard Effect.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

Relationships Among Auditory Discrimination, Adaptive Vocal Learning, and Perilaryngeal Muscle Activation in People With and Without Hyperfunctional Voice Disorders.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

Physiological Correlates of the Spectral Aggregate of the High-Passed Fundamental Frequency in Adductor Laryngeal Dystonia.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

Aerodynamic and Acoustic Characteristics of Nasal Airflow in Parkinson's Disease.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

Examining the Effect of Volitionally Altering Fundamental Frequency on Measures Associated With Vocal Hyperfunction.

Journal of voice : official journal of the Voice Foundation·2026
Same author

Speech Intelligibility in Speakers With Adductor Laryngeal Dystonia.

Journal of speech, language, and hearing research : JSLHR·2026
Same journal

Voice Activity and Participation Profile in Teachers with and without Risk of Voice Disorders in Türkiye.

Journal of voice : official journal of the Voice Foundation·2026
Same journal

Staged Interventions for Vocal Fold Paresis and Paralysis: A Proposed Decision Paradigm for Type 1 Thyroplasty.

Journal of voice : official journal of the Voice Foundation·2026
Same journal

Characteristics of Nerve Injury, Regeneration, and Vocal Fold Movement After Recurrent Laryngeal Nerve Electrocautery Injury.

Journal of voice : official journal of the Voice Foundation·2026
Same journal

Effects of Stabilization Exercises on Head Posture, Vocal Efficiency and Pain in Patients with Nonspecific Chronic Neck Pain.

Journal of voice : official journal of the Voice Foundation·2026
Same journal

Correlation Between Age, Gender, and Self-Perceived Voice Handicap in Lebanese Patients With Hoarseness.

Journal of voice : official journal of the Voice Foundation·2026
Same journal

From Mechanism to Impact: The Evolving Legacy of the New Investigator Research Forum.

Journal of voice : official journal of the Voice Foundation·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Foreign Accent and Forensic Speaker Identification in Voice Lineups: The Influence of Acoustic Features Based on Prosody
09:09

Foreign Accent and Forensic Speaker Identification in Voice Lineups: The Influence of Acoustic Features Based on Prosody

Published on: September 27, 2024

828

Transmasculine Voice Modification: A Case Study.

Daniel P Buckley1, Kimberly L Dahl2, Gabriel J Cler2

  • 1Department of Speech, Language, and Hearing Sciences, Boston University, Boston, Massachusetts; Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts.

Journal of Voice : Official Journal of the Voice Foundation
|June 3, 2019
PubMed
Summary
This summary is machine-generated.

Manual laryngeal therapy improved voice masculinity in a transmasculine individual, with acoustic and perceptual changes observed. However, these voice masculinization effects were temporary, returning to baseline after follow-up.

Keywords:
Case study researchCircumlaryngeal massageLaryngeal manual therapyTransgenderTransmasculineVoice therapy

More Related Videos

Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

951
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

7.2K

Related Experiment Videos

Last Updated: Jan 24, 2026

Foreign Accent and Forensic Speaker Identification in Voice Lineups: The Influence of Acoustic Features Based on Prosody
09:09

Foreign Accent and Forensic Speaker Identification in Voice Lineups: The Influence of Acoustic Features Based on Prosody

Published on: September 27, 2024

828
Asthma Detection Research Based on Voice Signal Processing and Machine Learning
04:04

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

951
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

7.2K

Area of Science:

  • Speech-Language Pathology
  • Acoustic Analysis
  • Voice Science

Background:

  • Voice changes are common during testosterone therapy for transmasculine individuals.
  • Further interventions may be sought for voice masculinization after hormonal therapy.
  • Manual laryngeal therapy offers a potential avenue for voice modification.

Observation:

  • A case study examined manual laryngeal therapy's impact on a transmasculine individual's voice.
  • Therapy included passive circumlaryngeal massage and active laryngeal reposturing with voicing.
  • Acoustic and perceptual measures were assessed pre- and post-therapy, and at follow-up.

Findings:

  • Acoustic measures showed decreased fundamental frequency (fo) and increased estimated vocal tract length post-therapy.
  • Listeners perceived the voice as most masculine immediately after the therapy session.
  • All observed voice changes reverted to baseline levels by the 3-day follow-up.

Implications:

  • Manual laryngeal therapy can induce temporary acoustic and perceptual voice changes in transmasculine individuals.
  • This highlights potential therapeutic targets for voice masculinization.
  • Further research is needed to explore sustained voice modification techniques.