Putamen Development in Children 12 to 21 Months Old
Roza Vlasova1, Niharika Gajawelli1,2, Yalin Wang3
1CIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Summary
Brain development in toddlers shows distinct growth patterns for the left and right putamen. These findings reveal specific timing and locations of putamen surface changes during early childhood.
Area of Science:
- Neuroscience
- Developmental Biology
- Pediatric Imaging
Background:
- The putamen, a key component of the basal ganglia, plays a crucial role in motor control and learning.
- Understanding the normative developmental trajectory of the putamen is essential for identifying potential neurodevelopmental disorders.
- Previous research has indicated changes in total putamen volume during childhood, but detailed surface development is less understood.
Purpose of the Study:
- To investigate the developmental trajectory of the putamen's surface morphology in children aged 13-21 months.
- To identify age-related surface changes in specific regions of the left and right putamen.
- To explore potential differences in the timing and location of growth between the left and right putamen.
Main Methods:
- Utilized multivariate surface tensor-based morphometry to analyze brain scans of children aged 13-21 months.
- Focused on detailed surface changes within the left and right putamen.
- Compared surface morphology across different age groups within the studied developmental window.
Main Results:
- Observed significant surface changes in the middle superior region of the left putamen between 12 and 15 months.
- Noted a deceleration in left putamen growth after 15 months.
- Detected prominent surface changes in the anterior part of the right putamen between 18 and 21 months.
Conclusions:
- The study demonstrates heterochronic (differentially timed) growth of the left and right putamen during early development.
- These findings suggest distinct developmental timelines for different functional subregions within the putamen.
- Results align with prior research on total putamen volume changes, providing a more detailed view of its surface development.
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